SAM-e is one of the critical compounds that is naturally occurring and is produced in our bodies. In fact SAM-e is found in every living organism. SAM-e has been available in several European countries for over 20 years as a prescription drug. It has proven to be effective and is being prescribed for depression, liver function, and for increased mobility for those with symptoms of osteoarthritis. In some studies it has been reported to have a lessening effect on dementia.

SAM-e has been available in the United States as a dietary supplement since 1999. We can say that SAM-e in sufficient quantity promotes:

1. An improvement in mood or well-being for most people.*
2. An improvement in liver function for some people.
3. An increase in mobility or a lessening of the loss of mobility that is believed to result from reduced pain and stiffness in the joints.

MOOD
SAM-e has proven to have a direct positive impact on most depressive states (with the exception of manic triggering in bipolar individuals). This impact comes with fewer and lesser side effects than commonly prescribed tri-cyclic anti-depressants. SAM-e supplementation appears to have positive and significant results within one to two weeks.

SAM-e, B-12, and folate levels are apparently tied together. Depressive individuals frequently show a reduced level of folate and a corresponding direct reduction in SAM-e levels. It is for this reason plus the lowering of homocysteine that folate, B-12, and B-6 supplemention is recommended along with S-adenosyl-methionine. Methionine has been mentioned as a precursor or needed component of SAM-e production.

Liver Function
Studies indicate that liver function can be dramatically improved with SAM-e supplementation for those that are in need of it. It is suggested that any one with concern about their liver function study the literature available and consult with their doctor about the benefits of S-adenosyl methionine. Liver dysfunction results from many causes including chemical (alcohol and solvents) and excessive consumption of certain drugs (acetaminophen and steroids) and lead intake.

Joint Function
SAM-e supplementation has shown to promote anti-inflammatory and cartilage building properties which enhance joint health and provide for better mobility. SAM-e supplementation is believed to increase proteoglycan molecules that are important in the cartilage building process.

Additional SAM-e information
SAM-e (S-adenosyl L Methionine/) occurs naturally in most body cells and fluids. It is important and plays a major role in biochemical reactions. The enzymatic transmethylation process contributes to the production, activation, and metabolism of DNA, hormones, neurotransmitters, nucleic acids, proteins, phospholipids, etc...

SAM-e that is made by the body or resulting from supplementation is metabolized into S-adenosylhomocysteine by the transfer of a 'methyl-group' to other compounds that accept the methyl-group (neurotransmitters and phospholipids). Hydrolysis of S-adenosylhomocysteine results in homocysteine and then cysteine. Cysteine is 'transulphurated' to sulphates, taurine, and glutathione. With sufficient 'B' vitamins the homocysteine is converted to methionine, one of the components for the body to produce more SAM-e.

SAM-e usually produces minimal side effects. Minor digestive tract discomfort is reported by a few of the SAM-e users. For these individuals it is suggested that they take their SAM-e after consuming a small amount of food. SAM-e should be enteric coated to allow the SAM-e to not be dissolved in the stomach where the benefical ingredients can be altered by stomach acid.

A person that is young and in top condition is believed to produce sufficient amounts of the natural compounds, including SAM-e, and additional oral supplementation is not believed to be warranted.

* Individuals that are under medical treatment for bipolar depression should, without fail, consult with their doctor before taking SAM-e products.

Information on this web site is provided for informational purposes and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing any medication. You should read carefully all product packaging. If you suspect that you have a medical problem, promptly contact your health care provider. Information and statements regarding dietary supplements have not been evaluated by the Food & Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.